Package 'powerCompRisk'

Title: Power Analysis Tool for Joint Testing Hazards with Competing Risks Data
Description: A power analysis tool for jointly testing the cause-1 cause-specific hazard and the any-cause hazard with competing risks data.
Authors: Qing Yang[aut], Wing K. Fung[aut], Eric Kawaguchi[ctb], Gang Li[aut, cre]
Maintainer: Eric Kawaguchi <[email protected]>
License: GPL-2
Version: 1.0.1
Built: 2024-11-22 03:04:53 UTC
Source: https://github.com/cran/powerCompRisk

Help Index


Power Analysis Tool for Joint Testing Hazards with Competing Risks Data.

Description

Power Analysis Tool for Joint Testing Hazards with Competing Risks Data.

Usage

powerCompRisk(alpha, beta, lambda_11, RR, HR_1, HR_all, attrition, r, f, a1)

Arguments

alpha

Type I error.

beta

Type II error.

lambda_11

Cause-1 cause-specific hazard in group 1.

RR

Relative risk of cause-1 failure versus the any-cause failure in group 1.

HR_1

Pre-specified cause-1 cause-specific hazard ratio between groups 1 and 2.

HR_all

Pre-specified any-cause hazard ratio between groups 1 and 2.

attrition

Attrition rate due to lost to follow-up.

r

Length of patient accrual period.

f

Maximum follow-up period.

a1

Sample allocation proportion for group 1.

Value

A dataframe with variables Chi2 Joint, Maximum Joint, Bonferroni methods. The first entry is the required number of cause-1 failures and the second entry is the required total number of patients.

References

Yang, Q., Fung, W.K., Li, G. (2017) Sample size determination for jointly testing a cause-specific hazard and the any-cause hazard in the presence of competing risks. UCLA Department of Biostatistics Technical Report.

Examples

library(powerCompRisk)
powerCompRisk(alpha = 0.05, beta = 0.2, lambda_11 = 0.3, RR = 0.8,
HR_1 = 1.44, HR_all = 1.33, attrition = 0.1, r = 1,f = 8, a1 = 0.5)